Pharmacokinetic (PK) studies in drug discovery and development
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Pharmacokinetic is a pharmaceutical procedure which gives the basic influence and time course of the sample drug compound.
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Pharmacokinetic
Assessment of absorption and presence of drug compound at the site of action give the minimum viable dose of a drug product.
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ADME Properties
Absorption determines the method of drug absorption in the body. The drug compound can enter the body via several routes such as liver, gastrointestinal tract, or skin.
Absorption
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Distribution
The drug distribution in PK studies is analyzed to assess the transfer of drug compound between different organs, tissues, etc.
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Metabolism
The process of metabolism in PK studies is an irreversible activity as the parent drug compound or PK sample is converted to metabolite in two phases.
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Excretion
The drug compounds are removed from the body during excretion.
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Importance of Pharmacokinetic Studies
The clinical PK studies form a relationship between the PK sample drug concentration at the site of action with the dosage regimen of the drug compound.
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Explain the Importance of Pharmacokinetic (PK) Studies in Drug Discovery and Development